Avery AP 7t Driver
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Avery AP 7t Driver
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Five additional patients had baseline MRSI data only. MBCT treatment consisted of 8 weekly classes each lasting 2.
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This 8-week MBCT group intervention used a clinician and participant manual developed by Segal et al. Postprocessing was performed using a previously published methodology [ 15 ]. Spectral arrays acquired with the interleaved flyback readout trajectory were combined and reordered to a rectilinear grid [ 16 ], processed with phase and frequency corrections individually for each coil, combined by weighting with coil sensitivities, and then quantified using LCModel [ Avery AP 7t ]. Segmentation of the brain was performed automatically on these images using Harvard—Oxford cortical and subcortical structural atlases [ 2021 ]. The signal from the MFG was partially suppressed by the outer-volume suppression bands; the small size of the pallidum meant that overlapping voxels may contain a relatively high portion of other tissue.
These two regions were therefore excluded from further analysis. The remaining five ROIs were analyzed and divided into right- and left-hemisphere sides.
Statistical analysis was performed using R www. Given the small sample Avery AP 7t of the study population, nonparametric statistic methods were used for data analysis, and the number Avery AP 7t participants in each group was required to be more than seven. Adjustment for multiple comparisons was not performed due to the exploratory nature of the study. Differences in baseline metabolite ratios between patients and controls were assessed using Wilcoxon rank-sum tests, and the effects of MBCT on metabolite ratios were assessed using Wilcoxon signed-rank tests. Spearman rank-correlation coefficients were calculated to determine the association between baseline metabolite ratios and baseline HAMD scores, between baseline metabolite ratios and reduction rates on HAMD scores, and between changes in metabolite ratios and reduction rates in HAMD scores.